Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort.

ABSTRACT:

Background

Pain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associated genes are associated with a constant-severe pain experience in RAP/CP patients.

Study

A retrospective study was done using North American Pancreatitis Study II (NAPS2) genotyped RAP and CP patients with completed case report forms (n = 1,357). Subjects were divided based on pattern of pain and pain severity as constant-severe pain (n = 787) versus not constant-severe pain (n = 570) to conduct a nested genome-wide assoc

SUBMITTER: Dunbar E 

PROVIDER: S-EPMC9124361 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature