SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy.

ABSTRACT: High-quality cutaneous wound healing is associated with rapid wound closure and a comfortable healing process. Currently, exosomes derived from mesenchymal stem cells displayed a prominent therapeutic effect on skin wound closure. But the therapeutic approaches for wound itching are very limited in clinical. Stem cells from human exfoliated deciduous teeth (SHED) may offer a unique exosome resource for cell-free therapeutics in potential clinical applications. Here, we investigated the common mechanisms underlying wound closure and unpleasant sensation of itching, focusing on the contribution of the SHED-derived exosome to immune response and wound itching during healing. The effects of SHED-derived exosomes on inflammatory wound healing were examined using lipopolysaccharide (LPS)-induced

SUBMITTER: Xie Y 

PROVIDER: S-EPMC9124392 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature