Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review.

ABSTRACT:

Background

Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary bladder) that were found on cystoscopy during treatment of castration-resistant prostate cancer.

Case presentation

In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer (AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplificatio

SUBMITTER: Masuda T 

PROVIDER: S-EPMC9124419 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature