Advances in Interventional Therapies for Painful Diabetic Neuropathy: A Systematic Review.

ABSTRACT:

Background

Painful diabetic neuropathy (PDN) is one of the major complications of diabetes mellitus. It is often debilitating and refractory to pharmaceutical therapies. Our goal was to systematically review and evaluate the strength of evidence of interventional management options for PDN and make evidence-based recommendations for clinical practice.

Methods

We searched PubMed, Scopus, Google Scholar, and Cochrane Llibrary and systematically reviewed all types of clinical studies on interventional management modalities for PDN.

Results

We identified and analyzed 10 relevant randomized clinical trials (RCTs), 8 systematic reviews/meta-analyses, and 5 observational studies of interventional modalities for PDN using pain as primary outcome. We assessed the risk of bias

SUBMITTER: Xu L 

PROVIDER: S-EPMC9124666 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature