Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery.

ABSTRACT:

Background

Phthalates are used in the manufacturing of consumer products, resulting in ubiquitous human exposure to phthalate mixtures. Previous work has suggested that phthalates display endocrine-disrupting capabilities, and exposure is associated with early delivery.

Objective

To assess mediating effects of hormone concentrations on associations between phthalate mixtures and preterm birth (PTB).

Methods

Repeated urinary phthalates and serum hormones were measured among 1011 women in the PROTECT Puerto Rico birth cohort from 2011-2019. We utilized ridge regression to create phthalate environmental risk scores (ERS), which represent weighted summaries of total phthalate exposure. Mediation analyses were conducted on a subset of 705 women. We additionally conducted f

SUBMITTER: Cathey AL 

PROVIDER: S-EPMC9124667 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature