TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma.

ABSTRACT:

Background

Integrins avβ6 and avβ8 are expressed by keratinocytes and transactivate latent TGFβ. In a murine model, integrin mediated activation of TGFβ has been shown to be critical in maintaining skin homeostasis, specifically playing roles in epidermal retention of Langerhans cells and resident memory cells T cells (Trm).

Objective

We examine expression of Integrins β6 and β8 in human skin, inflammatory skin disease, benign nevi, and melanoma and hypothesize that integrin expression is dysregulated in disease.

Methods

Using immunohistochemistry, we stained tissue from normal human skin (n = 8), psoriasis (n = 6), atopic dermatitis (n = 6), lichen planus (n = 5), benign nevi (n = 24), and melanoma (n = 25) with anti-integrin β6 and anti-integrin β8 to survey express

SUBMITTER: Nguyen BA 

PROVIDER: S-EPMC9124681 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature