Semaphorin 6D as an independent predictor for better prognosis in clear cell renal cell carcinoma.

ABSTRACT:

Introduction

Clear cell renal cell carcinoma (ccRCC) is the most common type of RCC and is associated with poor survival. However, the mechanisms underlying its development have not been thoroughly investigated. Semaphorin 6D (SEMA6D) is differentially expressed in various cancers, including lung adenocarcinoma and colorectal cancer. However, the role and mechanism of SEMA6D in ccRCC remain unexplored.

Materials and methods

We obtained 25 pairs of ccRCC tissue samples and 57 urine samples from patients with ccRCC and 52 urine samples from healthy volunteers. We performed RNA sequencing and compared the results with data from The Cancer Genome Atlas database to identify our gene of interest, SEMA6D. To verify the differential expression of SEMA6D, we used real-time quantitati

SUBMITTER: Duan J 

PROVIDER: S-EPMC9124703 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature