Spike-Associated Networks Predict Postsurgical Outcomes in Children With Refractory Epilepsy.

ABSTRACT:

Purpose

Up to half of the children undergoing epilepsy surgery will continue to have seizures (szs) despite a cortical resection or ablation. Functional connectivity has shown promise in better identifying the epileptogenic zone. We hypothesized that cortical areas showing high information outflow during interictal epileptiform discharges are part of the epileptogenic zone.

Methods

We identified 22 children with focal epilepsy who had undergone stereo electroencephalography, surgical resection or ablation, and had ≥1 year of postsurgical follow-up. The mean phase slope index, a directed measure of functional connectivity, was calculated for each electrode contact during interictal epileptiform discharges. The positive predictive value and negative predictive value for a sz-f

SUBMITTER: Bear JJ 

PROVIDER: S-EPMC9124720 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature