Evidence of Buprenorphine-precipitated Withdrawal in Persons Who Use Fentanyl.

ABSTRACT:

Objectives

Buprenorphine can precipitate withdrawal in opioid-dependent persons with recent fentanyl use. However, the prevalence of this phenomenon is not clinically established. We sought to evaluate the incidence of buprenorphine-precipitated withdrawal in persons who use fentanyl.

Methods

We collected self-report data on opioid withdrawal symptoms after buprenorphine use, and, as a comparator, after methadone use, in 1679 individuals seeking treatment for opioid use disorder across 49 addiction treatment centers in the United States.

Results

The odds of developing severe withdrawal symptoms significantly increased when taking buprenorphine within 24 hours after fentanyl use (OR = 5.202, 95% CI = 1.979-13.675, P = 0.001), and within 24 to 48hours after fentanyl use

SUBMITTER: Varshneya NB 

PROVIDER: S-EPMC9124721 | biostudies-literature | 2022 Jul-Aug 01

REPOSITORIES: biostudies-literature