Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC9124774 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Wu Xianbo X Xu Yihua Y Liang Qi Q Yang Xinwei X Huang Jianli J Wang Jie J Zhang Hong H Shi Jianyou J
Frontiers in pharmacology 20220509
The PI3K-Akt-mTOR pathway is a viable target for cancer treatment and can be used to treat various malignant tumours, including follicular lymphoma and breast cancer. Both enzymes, PI3K and mTOR, are critical in this pathway. Hence, in recent years, an array of inhibitors targeting these two targets have been studied, showing dual PI3K/mTOR inhibition compared with single targeting small molecule inhibitors. Inhibitors not only inhibit cell proliferation but also promote cell apoptosis. These in ...[more]