Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands.

ABSTRACT: Immunotherapy is considered a promising approach for cancer treatment. An important strategy for cancer immunotherapy is the use of cancer vaccines, which have been widely used for cancer treatment. Despite the great potential of cancer vaccines for cancer treatment, their therapeutic effects in clinical settings have been limited. The main reason behind the lack of significant therapeutic outcomes for cancer vaccines is believed to be the immunosuppressive tumor microenvironment (TME). The TME counteracts the therapeutic effects of immunotherapy and provides a favorable environment for tumor growth and progression. Therefore, overcoming the immunosuppressive TME can potentially augment the therapeutic effects of cancer immunotherapy in general and therapeutic cancer vaccines in particular

SUBMITTER: Rostamizadeh L 

PROVIDER: S-EPMC9124882 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature