Disrupted Spatiotemporal Complexity of Resting-State Electroencephalogram Dynamics Is Associated With Adaptive and Maladaptive Rumination in Major Depressive Disorder.

ABSTRACT: Patients with major depressive disorder (MDD) exhibit abnormal rumination, including both adaptive and maladaptive forms. However, the neural substrates of rumination in depression remain poorly understood. We hypothesize that divergent spatiotemporal complexity of brain oscillations would be associated with the levels of rumination in MDD. We employed the multi-scale entropy (MSE), power and phase-amplitude coupling (PAC) to estimate the complexity of rhythmic dynamics from the eye-closed high-density electroencephalographic (EEG) data in treatment-naive patients with MDD (n = 24) and healthy controls (n = 22). The depressive, brooding, and reflective subscales of the Ruminative Response Scale were assessed. MDD patients showed higher MSE in timescales finer than 5 (cluster

SUBMITTER: Wang J 

PROVIDER: S-EPMC9125314 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature