A reference tissue forward model for improved PET accuracy using within-scan displacement studies.

ABSTRACT: We report a novel forward-model implementation of the full reference tissue model (fFTRM) that addresses the fast-exchange approximation employed by the simplified reference tissue model (SRTM) by incorporating a non-zero dissociation time constant from the specifically bound compartment. The forward computational approach avoided errors associated with noisy and nonorthogonal basis functions using an inverse linear model. Compared to analysis by a multilinear single-compartment reference tissue model (MRTM), fFTRM provided improved accuracy for estimation of binding potentials at early times in the scan, with no worse reproducibility across sessions. To test the model's ability to identify small focal changes in binding potential using a within-scan challenge, we employed a nonhuman prima

SUBMITTER: Mandeville JB 

PROVIDER: S-EPMC9125481 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature