MRI evaluation of cerebral metabolic rate of oxygen (CMRO₂) in obstructive sleep apnea.

ABSTRACT: Patients with obstructive sleep apnea (OSA) are at elevated risk of developing systemic vascular disease and cognitive dysfunction. Here, cerebral oxygen metabolism was assessed in patients with OSA by means of a magnetic resonance-based method involving simultaneous measurements of cerebral blood flow rate and venous oxygen saturation in the superior sagittal sinus for a period of 10 minutes at an effective temporal resolution of 1.3 seconds before, during, and after repeated 24-second breath-holds mimicking spontaneous apneas, yielding, along with pulse oximetry-derived arterial saturation, whole-brain CMRO₂ via Fick's Principle. Enrolled subjects were classified based on their apnea-hypopnea indices into OSA (N = 31) and non-sleep apnea reference subjects (NSA = 21), and furt

SUBMITTER: Wu PH 

PROVIDER: S-EPMC9125486 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature