Treatment by biomarker-informed endotype vs guideline care in children with difficult-to-treat asthma.

ABSTRACT:

Background

Asthma is heterogeneous, contributing to difficulty in disease management.

Objective

To develop a biomarker-informed treatment model for difficult-to-treat (DTT) asthma and conduct a pilot feasibility study.

Methods

School-aged children (n = 21) with DTT asthma were enrolled and completed 3 medical visits (V1-V3). V2 and V3 were completed approximately 3.5 months and 12 months after V1, respectively. At V1, guideline care and adherence interventions were initiated, and blood samples were collected for asthma biomarker assessment. A personalized treatment algorithm was developed based on biomarkers (treatment by endotype) and was implemented at V2. Asthma outcomes were compared from V1 to V2 (guideline-based care) to V2 to V3 (guideline + biomarker-informed

SUBMITTER: Guilbert TW 

PROVIDER: S-EPMC9125694 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature