Serum Bicarbonate Concentration and Cause-Specific Mortality: The National Health and Nutrition Examination Survey 1999-2010.

ABSTRACT:

Objective

To assess the association between serum bicarbonate concentration and cause-specific mortality in the US general population.

Methods

A total of 31,195 individuals enrolled in the National Health and Nutrition Examination Survey between 1999 and 2010 were followed for a median 6.7 (interquartile range, 3.7-9.8) years. Cause-specific mortality was defined as cardiovascular, malignancy, and noncardiovascular/nonmalignancy causes. Cox proportional hazards adjusted for demographics, comorbidities, medications, and renal function were used to test the association between baseline serum bicarbonate and the outcomes of interest.

Results

Of the 2798 participants who died, 722 had a cardiovascular- and 620 had a malignancy-related death. Compared with participants wit

SUBMITTER: Al-Kindi SG 

PROVIDER: S-EPMC9125743 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature