Thalamic structural connectivity profiles in blepharospam/Meige's syndrome.

ABSTRACT:

Background

Blepharospasm is a debilitating focal dystonia characterized by involuntary eyelid spasms that can be accompanied by oromandibular muscle involvement (Meige's syndrome). Frequently observed abnormality in functional neuroimaging hints at an important position of the thalamus, that relays involved cortico-basal ganglia-cortical and cortico-cerebello-cortical circuits, within the abnormal network in blepharospasm.

Objective

To characterize abnormal cortico-thalamic structural/streamline connectivity (SC) patterns in the disease, as well as their potential co-occurrence with abnormal subcortico-thalamo-cortical projections using diffusion tractography.

Methods

Diffusion imaging was obtained in 17 patients with blepharospasm (5 with mild lower facial involvemen

SUBMITTER: Mantel T 

PROVIDER: S-EPMC9125780 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature