A crosstalk between gut and brain in sepsis-induced cognitive decline.

ABSTRACT:

Background

Sepsis is a potentially fatal disease characterized by acute organ failure that affects more than 30 million people worldwide. Inflammation is strongly associated with sepsis, and patients can experience impairments in memory, concentration, verbal fluency, and executive functioning after being discharged from the hospital. We hypothesize that sepsis disrupts the microbiota-gut-brain axis homeostasis triggering cognitive impairment. This immune activation persists during treatment, causing neurological dysfunction in sepsis survivors.

Methods

To test our hypothesis, adult Wistar rats were subjected to cecal-ligation and perforation (CLP) or sham (non-CLP) surgeries. The animals were subjected to the [¹¹C]PBR28 positron emission tomography (PET)/computed

SUBMITTER: Giridharan VV 

PROVIDER: S-EPMC9125851 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature