Plasma neuregulin 1 as a synaptic biomarker in Alzheimer's disease: a discovery cohort study.

ABSTRACT:

Background

Synaptic dysfunction is an early core feature of Alzheimer's disease (AD), closely associated with cognitive symptoms. Neuregulin 1 (NRG1) is a growth and differentiation factor with a key role in the development and maintenance of synaptic transmission. Previous reports have shown that changes in cerebrospinal fluid (CSF) NRG1 concentration are associated with cognitive status and biomarker evidence of AD pathology. Plasma biomarkers reflecting synaptic impairment would be of great clinical interest.

Objective

To measure plasma NRG1 concentration in AD patients in comparison with other neurodegenerative disorders and neurological controls (NC) and to study its association with cerebrospinal fluid (CSF) core AD and synaptic biomarkers.

Methods

This retrospe

SUBMITTER: Vrillon A 

PROVIDER: S-EPMC9125890 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature