Intestinal fatty acid binding protein is a disease biomarker in paediatric coeliac disease and Crohn's disease.

ABSTRACT:

Background

There is a clinical need to develop biomarkers of small bowel damage in coeliac disease and Crohn's disease. This study evaluated intestinal fatty acid binding protein (iFABP), a potential biomarker of small bowel damage, in children with coeliac disease and Crohn's disease.

Methods

The concentration iFABP was measured in plasma and urine of children with ulcerative colitis, coeliac disease, and Crohn's disease at diagnosis and from the latter two groups after treatment with gluten free diet (GFD) or exclusive enteral nutrition (EEN), respectively. Healthy children (Controls) were also recruited.

Results

138 children were recruited. Plasma but not urinary iFABP was higher in patients with newly diagnosed coeliac disease than Controls (median [Q1, Q3] coelia

SUBMITTER: Logan M 

PROVIDER: S-EPMC9125891 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature