Tumor microenvironment responsive Mn₃O₄ nanoplatform for in vivo real-time monitoring of drug resistance and photothermal/chemodynamic synergistic therapy of gastric cancer.

ABSTRACT:

Background

Postoperative chemotherapy for gastric cancer often causes multidrug resistance (MDR), which has serious consequences for therapeutic effects. Individualized treatment based on accurate monitoring of MDR will greatly improve patient survival.

Results

In this article, a self-enhanced Mn₃O₄ nanoplatform (MPG NPs) was established, which can react with glutathione to produce Mn²⁺ to enhance T1-weighted magnetic resonance imaging (MRI) and mediate in vivo real-time MDR monitoring. In vitro MRI results showed that MRI signals could be enhanced in the presence of hydrogen peroxide and glutathione and at acidic pH. In vivo MRI results indicated that MPG NPs could specifically target MDR cells, thereby realizing real-time monitoring of MDR

SUBMITTER: Li H 

PROVIDER: S-EPMC9125909 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature