N6-methyladenosine methylation modification patterns reveal immune profiling in pancreatic adenocarcinoma.

ABSTRACT:

Background

Several studies have revealed that N6-methyladenosine (m6A) regulation is involved in various biological processes and cancer progression. Nevertheless, the potential effects of m6A modifications in the tumor immune microenvironment (TIME) and on immune regulation in pancreatic adenocarcinoma (PAAD) remains unclear.

Methods

A consensus clustering algorithm was used to identify different m6A modification patterns and construct an m6A-associated gene signature based on 23 m6A regulators in PAAD. The CIBERSORT and ssGSEA algorithms were used to estimate the components of the immune cells in each sample. The PCA algorithm was used to develop the m6Ascore system for the evaluation of m6A modification patterns in each sample.

Results

Two m6A modification patterns

SUBMITTER: Xu H 

PROVIDER: S-EPMC9125922 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature