Serum proteome alterations during conventional and extracorporeal resuscitation in pigs.

ABSTRACT:

Background

Only a small number of patients survive an out-of-hospital cardiac arrest (CA) and can be discharged from hospital alive with a large percentage of these patients retaining neurological impairments. In recent years, extracorporeal cardiopulmonary resuscitation (ECPR) has emerged as a beneficial strategy to optimize cardiac arrest treatment. However, ECPR is still associated with various complications. To reduce these problems, a profound understanding of the underlying mechanisms is required. This study aims to investigate the effects of CA, conventional cardiopulmonary resuscitation (CPR) and ECPR using a whole-body reperfusion protocol (controlled and automated reperfusion of the whole body-CARL) on the serum proteome profiles in a pig model of refractory CA.

Method

SUBMITTER: Bernhard P 

PROVIDER: S-EPMC9125930 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature