Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Extracellular vesicle (EV) biomarkers have promising diagnosis and screening capacity for several cancers, but the diagnostic value for pancreatic cancer (PC) is controversial. The aim of our study was to review the diagnostic performance of EV biomarkers for PC.

Methods

We performed a systematic review of PubMed, Medline, and Web Of Science databases from inception to 18 Feb 2022. We identified studies reporting the diagnostic performance of EV biomarkers for PC and summarized the information of sensitivity, specificity, area under the curve (AUC), or receiver operator characteristic (ROC) curve) in according to a pre-designed data collection form. Pooled sensitivity and specificity was calculated using a random-effect model.

Results

We identified 39 studi

SUBMITTER: Jia E 

PROVIDER: S-EPMC9125932 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature