Virus-Mimicking Polymer Nanoparticles Targeting CD169⁺ Macrophages as Long-Acting Nanocarriers for Combination Antiretrovirals.

ABSTRACT: Monosialodihexosylganglioside (GM3)-presenting lipid-coated polymer nanoparticles (NPs) that recapitulate the sequestration of human immunodeficiency virus-1 (HIV-1) particles in CD169⁺ virus-containing compartments (VCCs) of macrophages were developed as carriers for delivery and sustained release of a combination of two antiretrovirals (ARVs), rilpivirine (RPV) and cabotegravir (CAB). RPV and CAB were co-loaded into GM3-presenting lipid-coated polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA) NPs without loss in potency of the drugs. GM3-presenting PLA NPs demonstrated the most favorable release properties and achieved inhibition of HIV-1 infection of primary human macrophages for up to 35 days. Intracellular localization of GM3-presenting PLA NPs in VCCs c

SUBMITTER: Eshaghi B 

PROVIDER: S-EPMC9126061 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature