Inhibition of Jumonji Histone Demethylases Selectively Suppresses HER2⁺ Breast Leptomeningeal Carcinomatosis Growth via Inhibition of GMCSF Expression.

ABSTRACT: HER2⁺ breast leptomeningeal carcinomatosis (HER2⁺ LC) occurs when tumor cells spread to cerebrospinal fluid-containing leptomeninges surrounding the brain and spinal cord, a complication with a dire prognosis. HER2⁺ LC remains incurable, with few treatment options. Currently, much effort is devoted toward development of therapies that target mutations. However, targeting epigenetic or transcriptional states of HER2⁺ LC tumors might efficiently target HER2⁺ LC growth via inhibition of oncogenic signaling; this approach remains promising but is less explored. To test this possibility, we established primary HER2⁺ LC (Lepto) cell lines from nodular HER2⁺ LC tissues. These lines are phenotypically CD326⁺CD4

SUBMITTER: Bhan A 

PROVIDER: S-EPMC9126130 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature