The Effects of Menopause on Neuromuscular Parameters of the Rat Vocal Folds.

ABSTRACT:

Objectives/hypothesis

Menopause adversely affecs power and endurance of the limb muscles. However, despite clinical observations that menopause corresponds to negative changes of the voice, the direct effects of estrogen deprivation on the thyroarytenoid muscles are unknown. The purpose of this study was to investigate the effects of estrogen deprivation via ovariectomy on three neuromuscular parameters of the thyroarytenoid muscles using a rat model.

Study design

Animal model.

Methods

Cryosections of vocal folds of 20 (10 control and 10 ovariectomized) female rats were stained to label neuromuscular junctions, fiber size, or parvalbumin levels using immunohistochemical techniques and compared between experimental groups.

Results

The neuromuscular junctions, th

SUBMITTER: Lenell C 

PROVIDER: S-EPMC9126135 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature