Genetically regulated gene expression and proteins revealed discordant effects.

ABSTRACT:

Background

Although gene-expression (GE) and protein levels are typically strongly genetically regulated, their correlation is known to be low. Here we investigate this phenomenon by focusing on the genetic background of this correlation in order to understand the similarities and differences in the genetic regulation of these omics layers.

Methods and results

We performed locus-wide association studies of 92 protein levels measured in whole blood for 2,014 samples of European ancestry and found that 66 are genetically regulated. Three female- and one male-specific effects were detected. We estimated the genetically regulated GE for all significant genes in 49 GTEx v8 tissues. A total of 7 proteins showed negative correlations with their respective GE across multiple tissues

SUBMITTER: Pott J 

PROVIDER: S-EPMC9126407 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature