Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration: A Systematic Review.

ABSTRACT:

Topic

To evaluate whether differences exist in systemic complement activation profiles in patients with early to intermediate nonexudative age-related macular degeneration (AMD) or geographic atrophy (GA) compared with control participants without AMD.

Clinical relevance

Complement inhibition has emerged as a therapeutic strategy for GA, although clinical trials to date have yielded mixed results. Despite these efforts, no clear consensus exists regarding what portions of the complement pathway are dysregulated in AMD or when this dysregulation occurs relative to AMD stage. Although past studies have compared systemic complement activation profiles in patients with AMD versus in control participants without AMD, differences in AMD case definition and differing analytical app

SUBMITTER: Lin JB 

PROVIDER: S-EPMC9126439 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature