Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease.

ABSTRACT:

Background

Whether the associations of time spent in screen-based sedentary activities with CHD vary by genetic susceptibility is currently unknown. The objective of this study was to examine the interplay of genetic susceptibility to CHD and two prevalent types of screen-based sedentary activities (television [TV] viewing and computer use) for CHD incidence.

Methods

This prospective cohort study included 373,026 individuals of European ancestry without prevalent CHD/stroke from UK Biobank data. Genetic susceptibility to CHD was assessed using weighted polygenic risk scores, calculated by summing the number of risk-increasing alleles among 300 single-nucleotide polymorphisms, multiplied by their corresponding effect estimates. TV viewing and computer use were assessed throug

SUBMITTER: Kim Y 

PROVIDER: S-EPMC9126635 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature