Functional Analysis of Serum Long Noncoding RNAs in Patients with Atrial Fibrillation.

ABSTRACT:

Objectives

Long noncoding RNAs (lncRNAs) are closely related to diverse diseases. However, its role in atrial fibrillation (AF) pathogenesis needs further exploration.

Design

We performed microarray analysis on the serum samples from 70 healthy volunteers and 70 AF patients. This study was aimed at detecting the levels of serum lncRNAs and mRNAs and bioinformatically analyze them to establish potential marker(s) for AF diagnosis. Receiver operating curve (ROC) and area under the curve (AUC) were employed to address the AF diagnostic power of lncRNAs.

Results

In the AF serum samples, 753 lncRNAs and 802 mRNAs (p ≤ 0.05; fold change ≥ 2) were upregulated, and 315 lncRNAs and 153 mRNAs were downregulated, as opposed to healthy serum samples. Using bioinformatic an

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9126683 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature