Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk.

ABSTRACT:

Background

Evidence is lacking on the impact of alcohol consumption on colorectal cancer (CRC) risk (overall and by age at diagnosis) by polygenic risk score (PRS) levels, and it is unclear how the magnitude of CRC risk associated with alcohol consumption compares to the magnitude of genetically determined risk.

Methods

Multiple logistic regression was used to assess the association between alcohol consumption and colorectal cancer (CRC) across PRS levels based on 140 CRC-related loci among 5104 CRC cases and 4131 controls from a large population-based case-control study. We compared the effects for alcohol consumption and PRS on CRC risk using the "Genetic Risk Equivalent (GRE)" for effective risk communication. Specific analyses were conducted for early-onset CRC (EOCRC, <

SUBMITTER: Chen X 

PROVIDER: S-EPMC9126769 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature