Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank.

ABSTRACT: Interest in the cerebellum is expanding given evidence of its contributions to cognition and emotion, and dysfunction in various psychopathologies. However, research into its genetic architecture and shared influences with liability for mental disorders is lacking. We conducted a genome-wide association study (GWAS) of total cerebellar volume and underlying cerebellar lobe volumes in 33,265 UK-Biobank participants. Total cerebellar volume was heritable (h²_SNP = 50.6%), showing moderate genetic homogeneity across lobes (h²_SNP from 35.4% to 57.1%; mean genetic correlation between lobes r_g ≈ 0.44). We identified 33 GWAS signals associated with total cerebellar volume, of which 6 are known to alter protein-coding gene structure, while a fu

SUBMITTER: Chambers T 

PROVIDER: S-EPMC9126806 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature