Lifespan extension with preservation of hippocampal function in aged system x_c^--deficient male mice.

ABSTRACT: The cystine/glutamate antiporter system x_c^- has been identified as the major source of extracellular glutamate in several brain regions as well as a modulator of neuroinflammation, and genetic deletion of its specific subunit xCT (xCT^-/-) is protective in mouse models for age-related neurological disorders. However, the previously observed oxidative shift in the plasma cystine/cysteine ratio of adult xCT^-/- mice led to the hypothesis that system x_c^- deletion would negatively affect life- and healthspan. Still, till now the role of system x_c^- in physiological aging remains unexplored. We therefore studied the effect of xCT deletion on the aging process of mice, with a particular focus on the immune syste

SUBMITTER: Verbruggen L 

PROVIDER: S-EPMC9126817 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature