Relationship between astrocyte reactivity, using novel ¹¹C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals.

ABSTRACT: Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer's disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired patients and 9 age-matched healthy controls) underwent brain scanning using the novel reactive astrocyte PET tracer ¹¹C-BU99008, ¹⁸F-FDG and ¹⁸F-florbetaben PET, and T1-weighted MRI. Differences between cognitively impaired patients and healthy controls in regional and voxel-wise levels of astrocyte reactivity, glucose metabolism, grey matter volume and amyloid load were explored, and their relationship to each other was assessed using Biological Parametric Mapping (BPM). Amyloid beta (Aβ)-positive patients showed g

SUBMITTER: Livingston NR 

PROVIDER: S-EPMC9126819 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature