SARS-CoV-2 detection using a nanobody-functionalized voltammetric device.

ABSTRACT:

Background

An ongoing need during the COVID-19 pandemic has been the requirement for accurate and efficient point-of-care testing platforms to distinguish infected from non-infected people, and to differentiate SARS-CoV-2 infections from other viruses. Electrochemical platforms can detect the virus via its envelope spike protein by recording changes in voltammetric signals between samples. However, this remains challenging due to the limited sensitivity of these sensing platforms.

Methods

Here, we report on a nanobody-functionalized electrochemical platform for the rapid detection of whole SARS-CoV-2 viral particles in complex media such as saliva and nasopharyngeal swab samples. The sensor relies on the functionalization of gold electrode surface with highly-oriented Llama

SUBMITTER: Pagneux Q 

PROVIDER: S-EPMC9126950 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature