Viral strategies for targeting spinal neuronal subtypes in adult wild-type rodents.

ABSTRACT: Targeting specific subtypes of interneurons in the spinal cord is primarily restricted to a small group of genetic model animals. Since the development of new transgenic model animals can be expensive and labor intensive, it is often difficult to generalize these findings and verify them in other model organisms, such as the rat, ferret or monkey, that may be more beneficial in certain experimental investigations. Nevertheless, endogenous enhancers and promoters delivered using an adeno-associated virus (AAV) have been successful in providing expression in specific subtypes of neurons in the forebrain of wildtype animals, and therefore may introduce a shortcut. GABAergic interneurons, for instance, have successfully been targeted using the mDlx promoter, which has recently been developed a

SUBMITTER: Kaur J 

PROVIDER: S-EPMC9126985 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature