Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults.

ABSTRACT:

Background

Aging is the primary risk factor for cardiovascular diseases, the leading cause of death worldwide. Age-related increases in systolic blood pressure (SBP) link advancing age to cardiovascular disease risk. A key mechanism mediating the increase in SBP with aging is stiffening of the large elastic arteries, which occurs due to increases in oxidative stress, inflammation, and vascular smooth muscle tone. Nicotinamide adenine dinucleotide (NAD⁺) is a key molecule in energy metabolism and cellular functioning which declines with advancing age and chronic disease. Dietary supplementation with NAD⁺ precursors, such as nicotinamide riboside, boosts NAD⁺ bioavailability and may improve cardiovascular health. Here, we present the protocol for a ra

SUBMITTER: Freeberg KA 

PROVIDER: S-EPMC9127073 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature