Dataset Information

Creatine Kinase and Mortality in Peritoneal Dialysis.

ABSTRACT:

Background

The association between serum creatine kinase and mortality in patients with peritoneal dialysis (PD) remained unknown.

Methods

We retrospectively collected data on 3,446 incident patients with from five PD centers in China between 1 January 2005 and 31 May 2020. Creatine kinase was collected 1 week before the start of PD. We examined the association between creatine kinase and mortality using Cox proportional hazards model.

Results

The median creatine kinase was 113 (range, 1.22-4,574) IU/L. With a median follow-up of 39.5 (range, 3.1-181.5) months, 763 (22.1%) all-cause deaths occurred, including 384 (11.1%) cardiovascular deaths. As compared with a creatine kinase of 111-179 IU/L (reference range), a higher creatine kinase (>179 IU/L) was associated with increased risks of all-cause mortality [hazards ratio (HR), 1.72; 95% CI, 1.35-2.00; E-value = 2.83] and cardiovascular mortality (HR, 1.44; 95% CI, 1.05-1.98; E-value = 2.24). As compared with the reference range, a lower creatine kinase (<111 IU/L) was associated with increased risks of all-cause mortality (HR, 1.40; 95% CI, 1.12-1.76; E-value = 2.15) and cardiovascular mortality (HR, 1.45; 95% CI, 1.08-1.94; E-value = 2.26). Interaction between creatine kinase and no hyperlipidemia (p = 0.034 for interaction) was observed.

Conclusion

A creatine kinase before the start of PD between 111 and 179 IU/L was associated with a lower risk of death than a higher or lower creatine kinase, resulting in a U-shaped association curve.

SUBMITTER: Wu X

PROVIDER: S-EPMC9127078 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Creatine Kinase and Mortality in Peritoneal Dialysis.

Wu Xianfeng X Zhou Lei L Zhan Xiaojiang X Wen Yueqiang Y Wang Xiaoyang X Feng Xiaoran X Wang Niansong N Peng Fenfen F Wu Junnan J

Frontiers in cardiovascular medicine 20220510

<h4>Background</h4>The association between serum creatine kinase and mortality in patients with peritoneal dialysis (PD) remained unknown.<h4>Methods</h4>We retrospectively collected data on 3,446 incident patients with from five PD centers in China between 1 January 2005 and 31 May 2020. Creatine kinase was collected 1 week before the start of PD. We examined the association between creatine kinase and mortality using Cox proportional hazards model.<h4>Results</h4>The median creatine kinase was ...[more]

PMID: 35620514

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Project description:BackgroundNew lipid-lowering therapy at the start of dialysis and measurement of lipid parameters over the follow-up period is not recommended in dialysis patients, which seems unappropriated in clinical practice. We aimed to examine the effect of hyperlipidemia on mortality in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).MethodsA retrospective cohort study was performed, including 2939 incident CAPD patients from five dialysis facilities between January 1, 2005, and December 31, 2018. The primary outcome was all-cause mortality. The association between hyperlipidemia at the start of CAPD and all-cause mortality was evaluated using Cox proportional hazards regression.ResultsOf 2939 with a median age of 50.0 (interquartile range, 39.0-61.0), 1697 (57.7%) were men, 533 (18.1%) had hyperlipidemia, 549 (18.7%) had diabetes mellitus, 1915 (65.2%) had hypertension, and 410 (14.0%) had a history of CVD. During the median follow-up period of 35.1 months, 519 (17.7%) died, including 402 (16.7%, 47.4/1000 patient-years) in the non-hyperlipidemia group and 117 (22.0%, 71.1/1000 patient-years) in the hyperlipidemia group. Over the overall follow-up period, patients with hyperlipidemia had an equally high risk of all-cause mortality throughout follow-up as those without hyperlipidemia ([HR] 1.04, 95% confidence interval [CI] 0.83 to 1.31). However, from the 48-month follow-up onwards, hyperlipidemia was associated with a 2.26 (95% CI 1.49 to 3.43)-time higher risk of all-cause mortality than non-hyperlipidemia. Hypertension modified the association between hyperlipidemia and all-cause mortality (P for interaction < 0.001). A significantly increased risk of all-cause mortality was observed among patients with hypertension (HR 2.27, 95%CI 1.44-3.58).ConclusionAmong CAPD patients, hyperlipidemia at the beginning of CAPD was associated with a high risk of long-term mortality. Hypertension may mediate the association. Our findings suggested that long-term lipid-lowering treatment should be used in those patients with hyperlipidemia.

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Dataset Information

Creatine Kinase and Mortality in Peritoneal Dialysis.

Background

Methods

Results

Conclusion

Publications

Creatine Kinase and Mortality in Peritoneal Dialysis.

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