DNAJC24 is a potential therapeutic target in hepatocellular carcinoma through affecting ammonia metabolism.

ABSTRACT: Evolutionarily conserved heat shock proteins are involved in the heat shock response of cells in response to changes in the external environment. In normal tissues, heat shock proteins can help cells survive in a rapidly changing environment. Likewise, in malignant tumors heat shock proteins may help tumor cells cope with external stresses as well as the stress of treatment. In this way they become accomplices of malignant tumors. Here we demonstrated for the first time that high expression of DNAJC24 (a heat shock protein) shortens survival in patients with HCC by immunohistochemical staining of 167 paired hepatocellular carcinomas and paraneoplastic tissues as well as data from public databases. In vitro experiments demonstrated that stimuli such as hypoxia, starvation and heat could upr

SUBMITTER: Li G 

PROVIDER: S-EPMC9127113 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature