Distinctive functional regime of endogenous lncRNAs in dark regions of human genome.

ABSTRACT: >98% of the human genome is composed of noncoding regions and >93% of these noncoding regions are actively transcribed, suggesting their criticality in the human genome. Yet <1% of these regions have been functionally characterized, leaving most of the human genomes in the dark. Here, this study processes petabyte level data and systematically decodes endogenous lncRNAs located in unannotated regions of the human genome and deciphers a distinctive functional regime of lncRNAs hidden in massive RNAseq data. LncRNAs divergently distribute across chromosomes, independent of protein-coding regions. Their transcriptions rarely initiate on promoters through polymerase II, but rather partially on enhancers. Yet conventional enhancer markers (e.g. H3K4me1) only account for a small proportion of ln

SUBMITTER: Wang A 

PROVIDER: S-EPMC9127114 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature