Associations between prognostic index scores and plasma neurofilament light in Huntington's disease.

ABSTRACT:

Introduction

The inclusion of premanifest Huntington's Disease (Pre-HD) subjects in clinical trials necessitates selecting those who are near transition to manifest Huntington's disease (Man-HD). We previously determined that plasma neurofilament light (NfL) levels are significantly correlated with predicted years to Man-HD onset, using established formulae. Recently, a new normalized prognostic index (PIN) score for predicting Pre-HD disease progression has been validated. Our objective was to determine whether plasma NfL levels are similarly associated with PIN score and PIN score-derived years to Man-HD onset (PIN-YTO).

Method

112 individuals (46 Pre-HD, 66 Man-HD) underwent blood sample collection and clinical assessment, inclusive of the Symbol Digit Modalities Test and

SUBMITTER: Parkin GM 

PROVIDER: S-EPMC9127124 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature