A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme.

ABSTRACT: Bacteria sometimes hedge their survival bets by concurrently activating response circuits leading to different phenotypes in isogenic populations. We show that the cyanobacterium Nostoc punctiforme responds to UV-A by concurrently producing the sunscreen scytonemin and differentiating into motile hormogonia but segregating the responses at the filament level. Mutational studies show that a four-gene partner-switching regulatory system (hcyA-D) orchestrates the cross-talk between the respective regulatory circuitries. Transcription of hormogonium genes and hcyA-D is upregulated by UVA through the scytonemin two-component regulator (scyTCR), hcyA-D being directly involved in signal transduction into the hormogonium response and its modulation by visible light. The

SUBMITTER: Klicki K 

PROVIDER: S-EPMC9127174 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature