Troponin T Is Negatively Associated With 3 Tesla Magnetic Resonance Peripheral Nerve Perfusion in Type 2 Diabetes.

ABSTRACT:

Objective

The pathogenesis of diabetic polyneuropathy (DN) is poorly understood and given the increasing prevalence of DN, there is a need for clinical or imaging biomarkers that quantify structural and functional nerve damage. While clinical studies have found evidence of an association between elevated levels of troponin T (hsTNT) and N-terminal pro brain natriuretic peptide (proBNP) with microvascular compromise in type 2 diabetes (T2D), their implication in mirroring DN nerve perfusion changes remains unclear. The objective of this study was, therefore, to investigate whether hsTNT and proBNP assays are associated with MRI nerve perfusion in T2D.

Methods

In this prospective cross-sectional single-center case-control study, 56 participants (44 with T2D, 12 healthy control

SUBMITTER: Jende JME 

PROVIDER: S-EPMC9127234 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature