Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum.

ABSTRACT:

Introduction

Neuroimaging heterogeneity in dementia has been examined using single modalities. We evaluated the associations of magnetic resonance imaging (MRI) atrophy and flortaucipir positron emission tomography (PET) clusters across the Alzheimer's disease (AD) spectrum.

Methods

We included 496 Alzheimer's Disease Neuroimaging Initiative participants with brain MRI, flortaucipir PET scan, and amyloid beta biomarker measures obtained. We applied a novel robust collaborative clustering (RCC) approach on the MRI and flortaucipir PET scans. We derived indices for AD-like (SPARE-AD index) and brain age (SPARE-BA) atrophy.

Results

We identified four tau (I-IV) and three atrophy clusters. Tau clusters were associated with the apolipoprotein E genotype. Atrophy clusters w

SUBMITTER: Toledo JB 

PROVIDER: S-EPMC9127251 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature