Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis.

ABSTRACT:

Background

Disruption in white matter integrity has been consistently observed in individuals with psychosis. However, whether such abnormalities are already present at illness onset or are related to downstream processes remains elusive. The study of adolescents with a recent onset of psychosis provides the opportunity to evaluate white matter integrity proximally to disease onset.

Methods

Twenty-six adolescents (aged 15.9 ± 1.3 years) with a first episode of psychosis (FEP) (less than 6 months duration) were compared with 26 age and sex-matched healthy controls (HC) (16.8 ± 2 years). In participants with a FEP, clinical diagnoses were confirmed after a minimum of 1 year follow-up (main categories: schizophrenia, bipolar disorder, or schizoaffective disorder). Anatomical im

SUBMITTER: Romero S 

PROVIDER: S-EPMC9127302 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature