Development and Validation of an 8-Gene Signature to Improve Survival Prediction of Colorectal Cancer.

ABSTRACT:

Background

Most prognostic signatures for colorectal cancer (CRC) are developed to predict overall survival (OS). Gene signatures predicting recurrence-free survival (RFS) are rarely reported, and postoperative recurrence results in a poor outcome. Thus, we aim to construct a robust, individualized gene signature that can predict both OS and RFS of CRC patients.

Methods

Prognostic genes that were significantly associated with both OS and RFS in GSE39582 and TCGA cohorts were screened via univariate Cox regression analysis and Venn diagram. These genes were then submitted to least absolute shrinkage and selection operator (LASSO) regression analysis and followed by multivariate Cox regression analysis to obtain an optimal gene signature. Kaplan-Meier (K-M), calibration

SUBMITTER: Zhou L 

PROVIDER: S-EPMC9127348 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature