Regenerative Calcium Currents in Renal Primary Cilia.

ABSTRACT: Polycystic kidney disease (PKD) is a leading cause of end-stage renal disease. PKD arises from mutations in proteins, one a Ca²⁺-conducting channel, expressed in the primary cilia of renal epithelial cells. A common hypothesis is that Ca²⁺ entering through ciliary ion channels may reduce cystogenesis. The cilia have at least two Ca²⁺-conducting channels: polycystin-2 (PC2) and TRPV4 (transient receptor potential (TRP) cation channel, subfamily V, member 4), but how substantially they can increase intraciliary Ca²⁺ is unknown. By recording channel activities in isolated cilia, conditions are identified under which the channels can increase free Ca²⁺ within the cilium by at least 500-fold through regenerative (positive-feedback) signalin

SUBMITTER: Kleene SJ 

PROVIDER: S-EPMC9127361 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature