Monte Carlo calculations of radiotherapy dose distributions within and around orthopaedic implants.

ABSTRACT:

Background and purpose

Cancer patients often require a titanium orthopaedic implant to support or replace lost bone. In radiation treatment, the dose distribution is perturbed causing regions of high and low dose at material interfaces. Since the survival of integrating bone tissue is critical to implant success, the aim of this study was to determine the dose distribution in and around the scaffold, when constructed from titanium or Poly-ether-ether-ketone (PEEK).

Materials and methods

The dose distributions in the pores and along boundaries for three implant scaffold designs were calculated using Monte-Carlo methods in Geant4/GATE, with the material taken as titanium or PEEK. The 3D dose distributions were analysed in MATLAB and segmented using image masks, yielding the do

SUBMITTER: Katsifis GA 

PROVIDER: S-EPMC9127420 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature