The context-dependent, combinatorial logic of BMP signaling.

ABSTRACT: Cell-cell communication systems typically comprise families of ligand and receptor variants that function together in combinations. Pathway activation depends on the complex way in which ligands are presented extracellularly and receptors are expressed by the signal-receiving cell. To understand the combinatorial logic of such a system, we systematically measured pairwise bone morphogenetic protein (BMP) ligand interactions in cells with varying receptor expression. Ligands could be classified into equivalence groups based on their profile of positive and negative synergies with other ligands. These groups varied with receptor expression, explaining how ligands can functionally replace each other in one context but not another. Context-dependent combinatorial interactions could be explaine

SUBMITTER: Klumpe HE 

PROVIDER: S-EPMC9127470 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature